'miR2Disease' is a manually curated database that provides a comprehensive resource of microRNA deregulation in various human diseases. The current version documents 1939 curated relationships between 299 human microRNAs and 94 human diseases, based on reviews of over 600 published papers. Each entry includes detailed information such as microRNA ID, disease name, relationship description, expression pattern, detection method, experimentally verified target genes, and a literature reference. The database offers a user-friendly interface for querying entries by microRNA ID, disease name, or target genes. Additionally, it provides a submission page for researchers to contribute new microRNA-disease relationships. miR2Disease is freely available at http://www.miR2Disease.org. The database aims to facilitate the understanding of microRNA's role in disease development and progression.'miR2Disease' is a manually curated database that provides a comprehensive resource of microRNA deregulation in various human diseases. The current version documents 1939 curated relationships between 299 human microRNAs and 94 human diseases, based on reviews of over 600 published papers. Each entry includes detailed information such as microRNA ID, disease name, relationship description, expression pattern, detection method, experimentally verified target genes, and a literature reference. The database offers a user-friendly interface for querying entries by microRNA ID, disease name, or target genes. Additionally, it provides a submission page for researchers to contribute new microRNA-disease relationships. miR2Disease is freely available at http://www.miR2Disease.org. The database aims to facilitate the understanding of microRNA's role in disease development and progression.