The study investigates the role of microRNA-33 (miR-33) in regulating hunger signaling in AgRP neurons, which are responsible for driving feeding behavior. Using mouse models, the researchers found that loss of miR-33 in AgRP neurons leads to increased feeding, obesity, and metabolic dysfunction. This effect is mediated through the regulation of multiple target genes involved in mitochondrial biogenesis and fatty acid metabolism. The findings suggest that miR-33 plays a critical role in controlling hunger by modulating bioenergetic processes associated with AgRP neuron activation, providing potential therapeutic targets for modulating feeding behavior and associated metabolic diseases.The study investigates the role of microRNA-33 (miR-33) in regulating hunger signaling in AgRP neurons, which are responsible for driving feeding behavior. Using mouse models, the researchers found that loss of miR-33 in AgRP neurons leads to increased feeding, obesity, and metabolic dysfunction. This effect is mediated through the regulation of multiple target genes involved in mitochondrial biogenesis and fatty acid metabolism. The findings suggest that miR-33 plays a critical role in controlling hunger by modulating bioenergetic processes associated with AgRP neuron activation, providing potential therapeutic targets for modulating feeding behavior and associated metabolic diseases.